Diagnosing and monitoring hepatobiliary disease, it is currently the most sensitive enzymatic indicator of liver disease. Ascertaining whether observed elevations of alkaline phosphatase are due to skeletal disease normal gamma-glutamyltransferase: GGT or reflect the presence of hepatobiliary disease elevated GGT.
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GGT is more sensitive than alkaline phosphatase ALPleucine aminopeptidase, aspartate transaminase, and alanine aminotransferase in detecting obstructive jaundice, cholangitis, and cholecystitis; its rise occurs earlier than with these other enzymes and persists longer.
Only modest elevations times normal occur in infectious hepatitis, and in this condition, GGT determinations are less useful diagnostically than are measurements of the transaminases. High elevations of GGT are also observed in patients with either primary or secondary metastatic neoplasms.
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An elevation of gamma-glutamyltransferase GGT activity is seen in any and all forms of liver disease, although the highest elevations are seen in intra- or posthepatic biliary obstruction. Elevated values can also indicate alcoholic cirrhosis or individuals who are heavy drinkers.
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